Research Library

The following research library is for informational use only. Curated Wellness provides this information as a service and does not receive compensation for studies referenced. This information should not be read to recommend or endorse any specific products. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease.

Select a curation to learn more about the published research we use to better understand nutrients and their roles.

Curations

1. Holscher H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes, 8(2), 172–184. https://doi.org/10.1080/19490976.2017.1290756 

2. Vighi, et al. (2008). Allergy and the gastrointestinal system. Clinical and Experimental Immunology. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515351/

3. McMullen, M. K., Whitehouse, J. M., & Towell, A. (2015). Bitters: Time for a New Paradigm. Evidence-based complementary and alternative medicine : eCAM, 2015, 670504. https://doi.org/10.1155/2015/670504 

4. Ouwehand, Arthur, “Antiallergic effects of probiotics,” Journal of Nutrition, Mar 2007 

5. Shi, L. H., Balakrishnan, K., Thiagarajah, K., Mohd Ismail, N. I., & Yin, O. S. (2016). Beneficial Properties of Probiotics. Tropical life sciences research27(2), 73–90. https://doi.org/10.21315/tlsr2016.27.2.6

6. Rao, R., & Samak, G. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of epithelial biology & pharmacology, 5(Suppl 1-M7), 47–54. https://doi.org/10.2174/1875044301205010047

7. Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A., & Cammarota, G. (2016). Digestive Enzyme Supplementation in Gastrointestinal Diseases. Current drug metabolism, 17(2), 187–193. https://doi.org/10.2174/138920021702160114150137

8. Money ME, Walkowiak J, Virgilio C, et al. Pilot study: a randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea. Frontline Gastroenterol. 2011;2:48-56. doi:10.1136/fg.2010.002253

1.https://www.clinicaleducation.org/resources/reviews/the-role-of-hcl-in-gastric-function-and-health/ 

2. Brugger, D., & Windisch, W. M. (2016). Subclinical zinc deficiency impairs pancreatic digestive enzyme activity and digestive capacity of weaned piglets. The British journal of nutrition, 116(3), 425–433. https://doi.org/10.1017/S0007114516002105 

3. McMullen, M. K., Whitehouse, J. M., & Towell, A. (2015). Bitters: Time for a New Paradigm. Evidence-based complementary and alternative medicine : eCAM, 2015, 670504. https://doi.org/10.1155/2015/670504

4.https://www.sciencedaily.com/releases/2016/06/160609115127.htm 

5. Holscher H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes, 8(2), 172–184. https://doi.org/10.1080/19490976.2017.1290756 

6. Money ME, Walkowiak J, Virgilio C, et al. Pilot study: a randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea. Frontline Gastroenterol. 2011;2:48-56. doi:10.1136/fg.2010.002253

7. Shi, L. H., Balakrishnan, K., Thiagarajah, K., Mohd Ismail, N. I., & Yin, O. S. (2016). Beneficial Properties of Probiotics. Tropical life sciences research27(2), 73–90. https://doi.org/10

1. McMullen, M. K., Whitehouse, J. M., & Towell, A. (2015). Bitters: Time for a New Paradigm. Evidence-based complementary and alternative medicine : eCAM, 2015, 670504. https://doi.org/10.1155/2015/670504

2. Holscher H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes, 8(2), 172–184. https://doi.org/10.1080/19490976.2017.1290756 

3. Ouwehand, Arthur, “Antiallergic effects of probiotics,” Journal of Nutrition, Mar 2007 

4. Shi, L. H., Balakrishnan, K., Thiagarajah, K., Mohd Ismail, N. I., & Yin, O. S. (2016). Beneficial Properties of Probiotics. Tropical life sciences research, 27(2), 73–90. https://doi.org/10.21315/tlsr2016.27.2.6

5. Pituch, A., Walkowiak, J., & Banaszkiewicz, A. (2013). Butyric acid in functional constipation. Przeglad gastroenterologiczny, 8(5), 295–298. https://doi.org/10.5114/pg.2013.38731

6. Banasiewicz, T., Krokowicz, Ł., Stojcev, Z., Kaczmarek, B. F., Kaczmarek, E., Maik, J., Marciniak, R., Krokowicz, P., Walkowiak, J., & Drews, M. (2013). Microencapsulated sodium butyrate reduces the frequency of abdominal pain in patients with irritable bowel syndrome. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 15(2

1. Shi, L. H., Balakrishnan, K., Thiagarajah, K., Mohd Ismail, N. I., & Yin, O. S. (2016). Beneficial Properties of Probiotics. Tropical life sciences research, 27(2), 73–90. https://doi.org/10.21315/tlsr2016.27.2.6

2. McMullen, M. K., Whitehouse, J. M., & Towell, A. (2015). Bitters: Time for a New Paradigm. Evidence-based complementary and alternative medicine : eCAM, 2015, 670504. https://doi.org/10.1155/2015/670504

3. Holscher H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes, 8(2), 172–184. https://doi.org/10.1080/19490976.2017.1290756 

4. Villarreal, J., Kahn, C. A., Dunford, J. V., Patel, E., & Clark, R. F. (2015). A retrospective review of the prehospital use of activated charcoal. The American journal of emergency medicine, 33(1), 56–59. https://doi.org/10.1016/j.ajem.2014.10.019 

5. Money ME, Walkowiak J, Virgilio C, et al. Pilot study: a randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea. Frontline Gastroenterol. 2011;2:48-56. doi:10.1136/fg.2010.002253


1. Frontiers | The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders | Psychiatry (frontiersin.org)

2.https://pubmed.ncbi.nlm.nih.gov/21784145/

3.https://www.healthline.com/nutrition/17-health-benefits-of-omega-3#TOC_TITLE_HDR_2

4.https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/#h2 

5.https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

6. Kennedy D. O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients, 8(2), 68. https://doi.org/10.3390/nu8020068 

7. Young, L. M., Pipingas, A., White, D. J., Gauci, S., & Scholey, A. (2019). A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals. Nutrients, 11(9), 2232. https://doi.org/10.3390/nu11092232 

8. Smith, S. M., & Vale, W. W. (2006). The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues in clinical neuroscience, 8(4), 383–395. https://doi.org/10.31887/DCNS.2006.8.4/ssmith 

9. Hooper, M.H., Carr, A. & Marik, P.E. The adrenal-vitamin C axis: from fish to guinea pigs and primates. Crit Care 23, 29 (2019). https://doi.org/10.1186/s13054-019-2332-x 

10. Wilson, J. L. (2017). Adrenal fatigue: The 21st century stress syndrome. Petaluma, CA: Smart Publications.

11. Yu-Yahiro J. A. (1994). Electrolytes and their relationship to normal and abnormal muscle function. Orthopedic nursing, 13(5), 38–40. https://doi.org/10.1097/00006416-199409000-00008

12. Hew-Butler, T., Loi, V., Pani, A., & Rosner, M. H. (2017). Exercise-Associated Hyponatremia: 2017 Update. Frontiers in medicine, 4, 21. https://doi.org/10.3389/fmed.2017.00021 

1.Frontiers | The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders | Psychiatry (frontiersin.org)

2.https://pubmed.ncbi.nlm.nih.gov/21784145/

3.https://www.healthline.com/nutrition/17-health-benefits-of-omega-3#TOC_TITLE_HDR_2

4.https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/#h2 

5.https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

6. Kennedy D. O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients, 8(2), 68. https://doi.org/10.3390/nu8020068 

7. Young, L. M., Pipingas, A., White, D. J., Gauci, S., & Scholey, A. (2019). A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals. Nutrients, 11(9), 2232. https://doi.org/10.3390/nu11092232 

8. Anderson, J. W., Baird, P., Davis, R. H., Jr, Ferreri, S., Knudtson, M., Koraym, A., Waters, V., & Williams, C. L. (2009). Health benefits of dietary fiber. Nutrition reviews, 67(4), 188–205. https://doi.org/10.1111/j.1753-4887.2009.00189.x 

9. Weickert, M. O., & Pfeiffer, A. F. (2008). Metabolic effects of dietary fiber consumption and prevention of diabetes. The Journal of nutrition, 138(3), 439–442. https://doi.org/10.1093/jn/138.3.439 

10.https://diabetes.diabetesjournals.org/content/62/5/1371

1.Frontiers | The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders | Psychiatry (frontiersin.org)

2.https://pubmed.ncbi.nlm.nih.gov/21784145/

3.https://www.healthline.com/nutrition/17-health-benefits-of-omega-3#TOC_TITLE_HDR_2

4.https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/#h2 

5.https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

6. Kennedy D. O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients, 8(2), 68. https://doi.org/10.3390/nu8020068 

7. Young, L. M., Pipingas, A., White, D. J., Gauci, S., & Scholey, A. (2019). A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals. Nutrients, 11(9), 2232. https://doi.org/10.3390/nu11092232 

8. Hooper, M.H., Carr, A. & Marik, P.E. The adrenal-vitamin C axis: from fish to guinea pigs and primates. Crit Care 23, 29 (2019). https://doi.org/10.1186/s13054-019-2332-x 

9.https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/learning-behaviour-and-cerebral-protein-kinase-c-antioxidant-status-lipid-composition-in-senescenceaccelerated-mouse-influence-of-a-phosphatidylcholinevitamin-b12-diet/EB998DCB0A8838004C0175915A439F13

10. Sartori SB, et al. (2012). Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment. DOI: 10.1016/j.neuropharm.2011.07.027 

11. Kirkland, A. E., Sarlo, G. L., & Holton, K. F. (2018). The Role of Magnesium in Neurological Disorders. Nutrients, 10(6), 730. https://doi.org/10.3390/nu10060730

12. Reddy, P., & Edwards, L. R. (2019). Magnesium Supplementation in Vitamin D Deficiency. American journal of therapeutics, 26(1), e124–e132. https://doi.org/10.1097/MJT.0000000000000538 

1. Anderson, J. W., Baird, P., Davis, R. H., Jr, Ferreri, S., Knudtson, M., Koraym, A., Waters, V., & Williams, C. L. (2009). Health benefits of dietary fiber. Nutrition reviews, 67(4), 188–205. https://doi.org/10.1111/j.1753-4887.2009.00189.x 

2. Clifford, T., Howatson, G., West, D. J., & Stevenson, E. J. (2015). The potential benefits of red beetroot supplementation in health and disease. Nutrients, 7(4), 2801–2822. https://doi.org/10.3390/nu7042801

3. Morisco, F., Lembo, V., Mazzone, G., Camera, S., & Caporaso, N. (2014). Coffee and liver health. Journal of clinical gastroenterology, 48 Suppl 1, S87–S90. https://doi.org/10.1097/MCG.0000000000000240

4. Trefts, E., Gannon, M., & Wasserman, D. H. (2017). The liver. Current biology : CB, 27(21), R1147–R1151. https://doi.org/10.1016/j.cub.2017.09.019

5.https://www.atherosclerosis-journal.com/article/S0021-9150(10)00595-2/fulltext

6.https://www.sciencedirect.com/science/article/abs/pii/S1388198111001120 

7. Ripps, H., & Shen, W. (2012). Review: taurine: a "very essential" amino acid. Molecular vision, 18, 2673–2686.

8. Liu, M., Yang, H., & Mao, Y. (2019). Magnesium and liver disease. Annals of translational medicine, 7(20), 578. https://doi.org/10.21037/atm.2019.09.70

9.https://aasld.confex.com/aasld/2020/meetingapp.cgi/Paper/21865

10. Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Tomeno, W., Imajo, K., Fujita, K., Yoneda, M., Kataoka, K., Taguri, M., Yamanaka, T., Seko, Y., Tanaka, S., Saito, S., Ono, M., Oeda, S., Eguchi, Y., Aoi, W., … Nakajima, A. (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC gastroenterology, 17(1), 96. https://doi.org/10.1186/s12876-017-0652-3

1. Marttinen, M., Ala-Jaakkola, R., Laitila, A., & Lehtinen, M. J. (2020). Gut Microbiota, Probiotics and Physical Performance in Athletes and Physically Active Individuals. Nutrients, 12(10), 2936. https://doi.org/10.3390/nu12102936 

2. Shuler, F. D., Wingate, M. K., Moore, G. H., & Giangarra, C. (2012). Sports health benefits of vitamin d. Sports health, 4(6), 496–501. https://doi.org/10.1177/1941738112461621 

3. Marawan A, Kurbanova N, Qayyum R. Association between serum vitamin D levels and cardiorespiratory fitness in the adult population of the USA. European Journal of Preventive Cardiology. 2019;26(7):750-755. doi:1177/2047487318807279 

4. McFarlin, B. K., Henning, A. L., & Venable, A. S. (2017). Oral Consumption of Vitamin K2 for 8 Weeks Associated With Increased Maximal Cardiac Output During Exercise. Alternative therapies in health and medicine, 23(4), 26–32. 

5. Lewis, E.J.H., Radonic, P.W., Wolever, T.M.S., & Wells, G.D. (2015). 21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo. Journal of the International Society of Sports Nutrition, 12(28). doi: 10.1186/s12970-015-0089-4 

6. Da Boit, M., Hunter, A.M., & Gray, S.R. (2017). Fit with good fat? The role of n-3 polyunsaturated fatty acids on exercise performance. Metabolism, 66, 45-54. doi: 10.1016/j.metabol.2016.10.007 

7. Price, C. T., Langford, J. R., & Liporace, F. A. (2012). Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. The open orthopaedics journal, 6, 143–149. https://doi.org/10.2174/1874325001206010143 

8.https://americanbonehealth.org/nutrition/minerals-for-bone-health/

1. Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. https://doi.org/10.3390/nu9111211 

2.https://www.karger.com/Article/FullText/496426 

3. La Fata G, Weber P, Mohajeri MH. Probiotics and the gut immune system: indirect regulation. Probiotics Antimicrob Proteins. 2018;10(1):11-21. 

4. Aziz N, Bonavida B. Activation of natural killer cells by probiotics. For Immunopathol Dis Therap. 2016;7(1-2):41-55. 

5. NAC - Research on Glutothione: Gaucher C, Boudier A, Bonetti J. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants (Basel). 2018 May;7(5):62. doi:10.3390/antiox7050062. 

6. Atkuri, K. R., Mantovani, J. J., Herzenberg, L. A., & Herzenberg, L. A. (2007). N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency. Current opinion in pharmacology, 7(4), 355–359. https://doi.org/10.1016/j.coph.2007.04.005 

7. Steinbrenner, H., Al-Quraishy, S., Dkhil, M. A., Wunderlich, F., & Sies, H. (2015). Dietary selenium in adjuvant therapy of viral and bacterial infections. Advances in nutrition (Bethesda, Md.), 6(1), 73–82. https://doi.org/10.3945/an.114.007575 

8. Huang, Z., Rose, A. H., & Hoffmann, P. R. (2012). The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxidants & redox signaling, 16(7), 705–743. https://doi.org/10.1089/ars.2011.4145 

9. Hemilä H. (2017). Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM open, 8(5), 2054270417694291. https://doi.org/10.1177/2054270417694291 

10. Haase, H., & Rink, L. (2009). The immune system and the impact of zinc during aging. Immunity & ageing : I & A, 6, 9. https://doi.org/10.1186/1742-4933-6-9 

11. Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. G. (2018). Role of Vitamin A in the Immune System. Journal of clinical medicine, 7(9), 258. https://doi.org/10.3390/jcm7090258 

12. Lewis, E. D., Meydani, S. N., & Wu, D. (2019). Regulatory role of vitamin E in the immune system and inflammation. IUBMB life, 71(4), 487–494. https://doi.org/10.1002/iub.1976 

13. Martens, P. J., Gysemans, C., Verstuyf, A., & Mathieu, A. C. (2020). Vitamin D's Effect on Immune Function. Nutrients, 12(5), 1248. https://doi.org/10.3390/nu12051

1. Frontiers | The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders | Psychiatry (frontiersin.org) 

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7. Kirkland, A. E., Sarlo, G. L., & Holton, K. F. (2018). The Role of Magnesium in Neurological Disorders. Nutrients, 10(6), 730. https://doi.org/10.3390/nu10060730 

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9. Krikorian, R., Eliassen, J. C., Boespflug, E. L., Nash, T. A., & Shidler, M. D. (2010). Improved cognitive-cerebral function in older adults with chromium supplementation. Nutritional neuroscience, 13(3), 116–122. https://doi.org/10.1179/147683010X12611460764084 

1.https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/sea-salt/faq-20058512 

2. Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin pharmacology and physiology, 27(1), 47–55. https://doi.org/10.1159/000351376 

3. Ghee: Canani, R. B., Costanzo, M. D., Leone, L., Pedata, M., Meli, R., & Calignano, A. (2011). Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World journal of gastroenterology, 17(12), 1519–1528. https://doi.org/10.3748/wjg.v17.i12.1519 

4.https://www.healthline.com/nutrition/ghee#Benefits-of-ghee 

5. Chacko, S. M., Thambi, P. T., Kuttan, R., & Nishigaki, I. (2010). Beneficial effects of green tea: a literature review. Chinese medicine, 5, 13. https://doi.org/10.1186/1749-8546-5-13 

6. House, J. D., Neufeld, J., & Leson, G. (2010). Evaluating the quality of protein from hemp seed (Cannabis sativa L.) products through the use of the protein digestibility-corrected amino acid score method. Journal of agricultural and food chemistry, 58(22), 11801–11807. https://doi.org/10.1021/jf102636b 

7. Zaineddin, A. K., Buck, K., Vrieling, A., Heinz, J., Flesch-Janys, D., Linseisen, J., & Chang-Claude, J. (2012). The association between dietary lignans, phytoestrogen-rich foods, and fiber intake and postmenopausal breast cancer risk: a German case-control study. Nutrition and cancer, 64(5), 652–665. https://doi.org/10.1080/01635581.2012.683227 

8. Phillips, K. M., Ruggio, D. M., & Ashraf-Khorassani, M. (2005). Phytosterol composition of nuts and seeds commonly consumed in the United States. Journal of agricultural and food chemistry, 53(24), 9436–9445. https://doi.org/10.1021/jf051505h 

9. Clifford, T., Howatson, G., West, D. J., & Stevenson, E. J. (2015). The potential benefits of red beetroot supplementation in health and disease. Nutrients, 7(4), 2801–2822. https://doi.org/10.3390/nu7042801 

10. *see mushroom category for individual mushrooms* Wachtel-Galor S, Yuen J, Buswell JA, et al. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 9. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92757/ 

11. Rao, V., Balachandran, B., Shen, H., Logan, A., & Rao, L. (2011). In vitro and in vivo antioxidant properties of the plant-based supplement greens+™. International journal of molecular sciences, 12(8), 4896–4908. https://doi.org/10.3390/ijms12084896 

Topics

Select a topic to learn more about the published research into nutrition and physiology that guides to our content.

Digestion

1.https://www.apa.org/topics/stress/body 

2.https://www.sciencedaily.com/releases/2016/06/160609115127.htm 

3.https://pubmed.ncbi.nlm.nih.gov/24668555/ 

4.https://pubmed.ncbi.nlm.nih.gov/24668555/ 

5.https://www.clinicaleducation.org/resources/reviews/the-role-of-hcl-in-gastric-function-and-health/ 

6. Shaik, F. A., Singh, N., Arakawa, M., Duan, K., Bhullar, R. P., & Chelikani, P. (2016). Bitter taste receptors: Extraoral roles in pathophysiology. The international journal of biochemistry & cell biology, 77(Pt B), 197–204. https://doi.org/10.1016/j.biocel.2016.03.011 

1.https://www.clinicaleducation.org/resources/reviews/the-use-of-vitamin-u-for-gastric-ulcer-recovery/

2. Patel, A.D. et al. (2012). Review on Biochemical Importance of Vitamin-U. J. Chem. Pharm. Res., 4(1), 209-215. Retrieved from: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.694.9840&rep=rep1&type=pdf 

3. Rao, R., & Samak, G. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of epithelial biology & pharmacology, 5(Suppl 1-M7), 47–54. https://doi.org/10.2174/1875044301205010047 

4. Carlson, J. L., Erickson, J. M., Lloyd, B. B., & Slavin, J. L. (2018). Health Effects and Sources of Prebiotic Dietary Fiber. Current developments in nutrition, 2(3), nzy005. https://doi.org/10.1093/cdn/nzy005 

1. Lim, H. S., Kim, S. K., & Hong, S. J. (2018). Food Elimination Diet and Nutritional Deficiency in Patients with Inflammatory Bowel Disease. Clinical nutrition research, 7(1), 48–55. https://doi.org/10.7762/cnr.2018.7.1.48 

2. Mu, Q., Kirby, J., Reilly, C. M., & Luo, X. M. (2017). Leaky Gut As a Danger Signal for Autoimmune Diseases. Frontiers in immunology, 8, 598. https://doi.org/10.3389/fimmu.2017.00598 

3.https://www.apa.org/topics/stress/body#:~:text=Stress%20can%20affect%20digestion%2C%20and,bacteria%20to%20enter%20the%20body

4. Holscher H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes, 8(2), 172–184. https://doi.org/10.1080/19490976.2017.1290756 

5.https://www.clinicaleducation.org/resources/reviews/the-use-of-vitamin-u-for-gastric-ulcer-recovery/ 

6. Rao, R., & Samak, G. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of epithelial biology & pharmacology, 5(Suppl 1-M7), 47–54. https://doi.org/10.2174/1875044301205010047 

7. Peyrot des Gachons, C., & Breslin, P. A. (2016). Salivary Amylase: Digestion and Metabolic Syndrome. Current diabetes reports, 16(10), 102. https://doi.org/10.1007/s11892-016-0794-7 

8. McMullen, M. K., Whitehouse, J. M., & Towell, A. (2015). Bitters: Time for a New Paradigm. Evidence-based complementary and alternative medicine : eCAM, 2015, 670504. https://doi.org/10.1155/2015/670504 

9. Brugger, D., & Windisch, W. M. (2016). Subclinical zinc deficiency impairs pancreatic digestive enzyme activity and digestive capacity of weaned piglets. The British journal of nutrition, 116(3), 425–433. https://doi.org/10.1017/S0007114516002105 

10. Klinder, A., Shen, Q., Heppel, S., Lovegrove, J. A., Rowland, I., & Tuohy, K. M. (2016). Impact of increasing fruit and vegetables and flavonoid intake on the human gut microbiota. Food & function, 7(4), 1788–1796. https://doi.org/10.1039/c5fo01096a 

11. Skrovanek, S., DiGuilio, K., Bailey, R., Huntington, W., Urbas, R., Mayilvaganan, B., Mercogliano, G., & Mullin, J. M. (2014). Zinc and gastrointestinal disease. World journal of gastrointestinal pathophysiology, 5(4), 496–513. https://doi.org/10.4291/wjgp.v5.i4.496 

1.https://www.clinicaleducation.org/resources/reviews/the-role-of-hcl-in-gastric-function-and-health/ 

2. Brugger D, Windisch W.  Subclinical Zinc Deficiency Impairs Pancreatic Digestive Enzyme Activity and Digestive Capacity of Weaned Piglets. British Journal of Nutrition. 2016.

1. Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J. D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014). Intestinal permeability--a new target for disease prevention and therapy. BMC gastroenterology, 14, 189. https://doi.org/10.1186/s12876-014-0189-7

2. Skrovanek, S., DiGuilio, K., Bailey, R., Huntington, W., Urbas, R., Mayilvaganan, B., Mercogliano, G., & Mullin, J. M. (2014). Zinc and gastrointestinal disease. World journal of gastrointestinal pathophysiology, 5(4), 496–513. https://doi.org/10.4291/wjgp.v5.i4.496

3. Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2011). Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 62(6), 591–599.

4. Holscher H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes, 8(2), 172–184. https://doi.org/10.1080/19490976.2017.1290756

5. CHENEY, G., WAXLER, S. H., & MILLER, I. J. (1956). Vitamin U therapy of peptic ulcer; experience at San Quentin Prison. California medicine, 84(1), 39–42. 

6. Rao, R., & Samak, G. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. J Epithel Biol Pharmacology. doi:doi:10.2174/1875044301205010047.

1. Magnúsdóttir, S., Ravcheev, D., de Crécy-Lagard, V., & Thiele, I. (2015). Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes. Frontiers in genetics, 6, 148. https://doi.org/10.3389/fgene.2015.00148

2. Cenit, M. C., Sanz, Y., & Codoñer-Franch, P. (2017). Influence of gut microbiota on neuropsychiatric disorders. World journal of gastroenterology, 23(30), 5486–5498. https://doi.org/10.3748/wjg.v23.i30.5486

3. Sokol H, Leducq V, Aschard H, et al Fungal microbiota dysbiosis in IBD Gut 2017;66:1039-1048. 

4. Yao, K., Zeng, L., He, Q., Wang, W., Lei, J., & Zou, X. (2017). Effect of Probiotics on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Meta-Analysis of 12 Randomized Controlled Trials. Medical science monitor : international medical journal of experimental and clinical research, 23, 3044–3053. https://doi.org/10.12659/msm.902600.

1.https://chriskresser.com/role-of-gut-microbiome-in-the-immune-system/ 

2. Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011). Human nutrition, the gut microbiome and the immune system. Nature, 474(7351), 327–336. https://doi.org/10.1038/nature10213

3. Statovci, D., Aguilera, M., MacSharry, J., & Melgar, S. (2017). The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Frontiers in immunology, 8, 838. https://doi.org/10.3389/fimmu.2017.00838 

1. Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., ... & Li, X. (2018). Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proceedings of the National Academy of Sciences, 115(13), E2960-E2969.

1.https://www.niddk.nih.gov/health-information/digestive-diseases/constipation/symptoms-causes

2. Weickert, M. O., & Pfeiffer, A. F. (2008). Metabolic effects of dietary fiber consumption and prevention of diabetes. The Journal of nutrition, 138(3), 439–442. https://doi.org/10.1093/jn/138.3.439 

3. Anderson, J. W., Baird, P., Davis, R. H., Jr, Ferreri, S., Knudtson, M., Koraym, A., Waters, V., & Williams, C. L. (2009). Health benefits of dietary fiber. Nutrition reviews, 67(4), 188–205. https://doi.org/10.1111/j.1753-4887.2009.00189.x 

4. Mori, S., Tomita, T., Fujimura, K., Asano, H., Ogawa, T., Yamasaki, T., Kondo, T., Kono, T., Tozawa, K., Oshima, T., Fukui, H., Kimura, T., Watari, J., & Miwa, H. (2019). A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation. Journal of neurogastroenterology and motility, 25(4), 563–575. https://doi.org/10.5056/jnm18194

5. https://www.niddk.nih.gov/health-information/digestive-diseases/constipation-children/eating-diet-nutrition 

6.Kids and Exercise (for Parents) - Nemours KidsHealth or https://kidshealth.org/en/parents/exercise.html

1. Riegler, G., & Esposito, I. (2001). Bristol scale stool form. A still valid help in medical practice and clinical research. Techniques in coloproctology, 5(3), 163–164. https://doi.org/10.1007/s101510100019 

2. Zuckerman, G. R., Trellis, D. R., Sherman, T. M., & Clouse, R. E. (1995). An objective measure of stool color for differentiating upper from lower gastrointestinal bleeding. Digestive diseases and sciences, 40(8), 1614–1621. https://doi.org/10.1007/BF02212679 

3.https://www.mayoclinic.org/diseases-conditions/constipation/symptoms-causes/syc-20354253 

Energy + Mood + Stress

1. Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018). Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders. Frontiers in psychiatry, 9, 44. https://doi.org/10.3389/fpsyt.2018.00044 

2. Pal, G. K., Velkumary, S., & Madanmohan (2004). Effect of short-term practice of breathing exercises on autonomic functions in normal human volunteers. The Indian journal of medical research, 120(2), 115–121.

3. Godek D, Freeman AM. Physiology, Diving Reflex. [Updated 2020 Sep 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538245/ 

1. Pal, G. K., Ganesh, V., Karthik, S., Nanda, N., & Pal, P. (2014). The effects of short-term relaxation therapy on indices of heart rate variability and blood pressure in young adults. American journal of health promotion : AJHP, 29(1), 23–28. https://doi.org/10.4278/ajhp.130131-QUAN-52

2. Streeter, C. C., Gerbarg, P. L., Whitfield, T. H., Owen, L., Johnston, J., Silveri, M. M., Gensler, M., Faulkner, C. L., Mann, C., Wixted, M., Hernon, A. M., Nyer, M. B., Brown, E. R., & Jensen, J. E. (2017). Treatment of Major Depressive Disorder with Iyengar Yoga and Coherent Breathing: A Randomized Controlled Dosing Study. Journal of Alternative and Complementary Medicine (New York, N.Y.), 23(3), 201–207. https://doi.org/10.1089/acm.2016.0140

1.https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

2. Kennedy D. O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients, 8(2), 68. https://doi.org/10.3390/nu8020068 

1. Smith, S. M., & Vale, W. W. (2006). The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues in clinical neuroscience, 8(4), 383–395. https://doi.org/10.31887/DCNS.2006.8.4/ssmith 

2. Veldhuis JD, Sharma A, Roelfsema F. Age-dependent and gender-dependent regulation of hypothalamic-adrenocorticotropic-adrenal axis. Endocrinol Metab Clin North Am. 2013 Jun;42(2):201-25. doi: 10.1016/j.ecl.2013.02.002. Epub 2013 Mar 13. PMID: 23702398; PMCID: PMC3675779. 

3. Al-Dujaili, E., Ashmore, S., & Tsang, C. (2019). A Short Study Exploring the Effect of the Glycaemic Index of the Diet on Energy intake and Salivary Steroid Hormones. Nutrients, 11(2), 260. https://doi.org/10.3390/nu11020260 

4. Hooper, M.H., Carr, A. & Marik, P.E. The adrenal-vitamin C axis: from fish to guinea pigs and primates. Crit Care 23, 29 (2019). https://doi.org/10.1186/s13054-019-2332-x 

1. Morisco, F., Lembo, V., Mazzone, G., Camera, S., & Caporaso, N. (2014). Coffee and liver health. Journal of clinical gastroenterology, 48 Suppl 1, S87–S90. https://doi.org/10.1097/MCG.0000000000000240

2. Clifford, T., Howatson, G., West, D. J., & Stevenson, E. J. (2015). The potential benefits of red beetroot supplementation in health and disease. Nutrients, 7(4), 2801–2822. https://doi.org/10.3390/nu7042801

3. Gupta, V., Mah, X. J., Garcia, M. C., Antonypillai, C., & van der Poorten, D. (2015). Oily fish, coffee and walnuts: Dietary treatment for nonalcoholic fatty liver disease. World journal of gastroenterology, 21(37), 10621–10635. https://doi.org/10.3748/wjg.v21.i37.10621 

1. Lindsay EK, Young S, Brown KW, Smyth JM, Creswell JD. Mindfulness training reduces loneliness and increases social contact in a randomized controlled trial. Proc Natl Acad Sci U S A. 2019;116(9):3488-3493. doi:10.1073/pnas.1813588116

2.https://linguistics.ucla.edu/people/hayes/Teaching/papers/MuellerAndOppenheimer2014OnTakingNotesByHand.pdf

3. Goyal M, Singh S, Sibinga EM, Gould NF, Rowland-Seymour A, Sharma R, Berger Z, Sleicher D, Maron DD, Shihab HM, Ranasinghe PD, Linn S, Saha S, Bass EB, Haythornthwaite JA. Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern Med. 2014 Mar;174(3):357-68. doi: 10.1001/jamainternmed.2013.13018. PMID: 24395196; PMCID: PMC4142584.

4. Rusch HL, Rosario M, Levison LM, et al. The effect of mindfulness meditation on sleep quality: a systematic review and meta-analysis of randomized controlled trials. Ann N Y Acad Sci. 2019;1445(1):5-16. doi:10.1111/nyas.13996

1. Statovci, D., Aguilera, M., MacSharry, J., & Melgar, S. (2017). The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Frontiers in immunology, 8, 838. https://doi.org/10.3389/fimmu.2017.00838

2.https://www.apa.org/topics/stress/body 

1. Nutritional Therapy Association. (2017). Hydration Module Slides [PDF document]. Retrieved from https://nta.brightspace.com/d2l/le/content/10074/viewContent/101881/View

2. Ballantyne, Sarah (2017). Paleo Principles. Las Vegas, NV: Victory Belt Publishing, Inc.

3. Tardy, A. L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020). Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients, 12(1), 228. https://doi.org/10.3390/nu12010228

4. Haas, Elson. (2006). Staying Healthy with Nutrition. Berkeley, CA: Celestial Arts.

5. Lynch SR, Cook JD. Interaction of vitamin C and iron. Ann N Y Acad Sci. 1980;355:32-44. doi: 10.1111/j.1749-6632.1980.tb21325.x. PMID: 6940487.

6. Ballantyne, Sarah. (2018, February 19).Is Breakfast The Most Important Meal of the Day? New Science Has Answers! The Paleo Mom

7.https://www.thepaleomom.com/breakfast-important-meal-day-new-science-answers/

8.https://www.hsph.harvard.edu/nutritionsource/food-features/oats/

9.https://www.hsph.harvard.edu/nutritionsource/food-features/chia-seeds/

1.https://www.psychiatry.org/newsroom/apa-public-opinion-poll-annual-meeting-2018 

2.Thakur, K., Tomar, S. K., Singh, A. K., Mandal, S., & Arora, S. (2017). Riboflavin and health: A review of recent human research. Critical reviews in food science and nutrition, 57(17), 3650–3660. https://doi.org/10.1080/10408398.2016.1145104

3.Almeida, O. P., Ford, A. H., Hirani, V., Singh, V., vanBockxmeer, F. M., McCaul, K., & Flicker, L. (2014). B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial. The British journal of psychiatry : the journal of mental science, 205(6), 450–457. https://doi.org/10.1192/bjp.bp.114.145177

4.Kirkland, A. E., Sarlo, G. L., & Holton, K. F. (2018). The Role of Magnesium in Neurological Disorders. Nutrients, 10(6), 730. https://doi.org/10.3390/nu10060730

5. Sartori SB, et al. (2012). Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment. DOI: 10.1016/j.neuropharm.2011.07.027 

6. Reddy, P., & Edwards, L. R. (2019). Magnesium Supplementation in Vitamin D Deficiency. American journal of therapeutics, 26(1), e124–e132. https://doi.org/10.1097/MJT.0000000000000538 

7. Boyle NB, et. al. (2017). The effects of magnesium supplementation on subjective anxiety and stress – A systematic review. DOI: 10.3390/nu9050429 

8.http://www.biomed.cas.cz/physiolres/pdf/64%20Suppl%202/64_S101.pdf 

9. Sue Penckofer, Mary Byrn, William Adams, Mary Ann Emanuele, Patricia Mumby, Joanne Kouba, Diane E. Wallis, "Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes", Journal of Diabetes Research, vol. 2017, Article ID 8232863, 11 pages, 2017. https://doi.org/10.1155/2017/8232863

1.https://www.health.harvard.edu/blog/nutritional-strategies-to-ease-anxiety-201604139441

2.https://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml

3. Jaatinen, N., Korpela, R., Poussa, T., Turpeinen, A., Mustonen, S., Merilahti, J., & Peuhkuri, K. (2014). Effects of daily intake of yoghurt enriched with bioactive components on chronic stress responses: a double-blinded randomized controlled trial. International journal of food sciences and nutrition, 65(4), 507–514. https://doi.org/10.3109/09637486.2014.880669

4. Hansen, A. L., Olson, G., Dahl, L., Thornton, D., Grung, B., Graff, I. E., Frøyland, L., & Thayer, J. F. (2014). Reduced anxiety in forensic inpatients after a long-term intervention with Atlantic salmon. Nutrients, 6(12), 5405–5418. https://doi.org/10.3390/nu6125405

5. White, D. J., de Klerk, S., Woods, W., Gondalia, S., Noonan, C., & Scholey, A. B. (2016). Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients, 8(1), 53. https://doi.org/10.3390/nu8010053 

6. Mao, J. J., Xie, S. X., Keefe, J. R., Soeller, I., Li, Q. S., & Amsterdam, J. D. (2016). Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine : international journal of phytotherapy and phytopharmacology, 23(14), 1735–1742. https://doi.org/10.1016/j.phymed.2016.10.012

1.Glycogen Metabolism - Biochemistry - NCBI Bookshelf (nih.gov)

2. Gross, L. S., Li, L., Ford, E. S., & Liu, S. (2004). Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. The American journal of clinical nutrition, 79(5), 774–779. https://doi.org/10.1093/ajcn/79.5.774 

3. Oomen, C. M., Ocké, M. C., Feskens, E. J., van Erp-Baart, M. A., Kok, F. J., & Kromhout, D. (2001). Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study. Lancet (London, England), 357(9258), 746–751. https://doi.org/10.1016/s0140-6736(00)04166-0

1.https://www.hsph.harvard.edu/nutritionsource/vitamins/vitamin-b/

2.https://www.healthline.com/health/b12-vitamins-for-energy

3. Zhao, J. V., Schooling, C. M., & Zhao, J. X. (2018). The effects of folate supplementation on glucose metabolism and risk of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Annals of epidemiology, 28(4), 249–257.e1. https://doi.org/10.1016/j.annepidem.2018.02.001

4.https://www.health.harvard.edu/mind-and-mood/probiotics-may-help-boost-mood-and-cognitive-function

5.https://www.healthline.com/nutrition/gut-brain-connection#:~:text=Your%20gut%20microbes%20also%20produce,%2Dlike%20behavior%20(%2014%20)

6. Clifford, T., Howatson, G., West, D. J., & Stevenson, E. J. (2015). The potential benefits of red beetroot supplementation in health and disease. Nutrients, 7(4), 2801–2822. https://doi.org/10.3390/nu7042801

7.https://www.medicalnewstoday.com/articles/153188#imbalance

8.https://www.news-medical.net/health/Health-Benefits-of-Prebiotics.aspx   

9. Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019). Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications. Foods (Basel, Switzerland), 8(3), 92. https://doi.org/10.3390/foods8030092

Men's, Women's, and Children's Health and Nutrition

1. Bohon, T. M., & Goolsby, M. A. (2013). The Role of Vitamin D Supplements in Women's Health. Clinical medicine insights. Women's health, 6, 67–70. https://doi.org/10.4137/CMWH.S11067

2.https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/

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Food, Recipes and Macronutrients

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