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††USA Functional Medicine MDs, DOs, NDs, DCs and Nutrition Professionals surveyed in 2025 for Designs for Health.
L-5-MTHF provides 1 mg (1,700 mcg DFE) of natural, biologically active form of folate, which is essential for cell division and growth, and also works to balance the homocysteine pathway.* This formula provides folate in the bioidentical, bioactive form, 5-methyltetrahydrofolate. In L-5-MTHF, the “L” signifies that it is an all-natural [6S] isomer, and this is the active circulating form of folate found in the body and one of the several forms found in food. In nature, this is found only as this [6S] isomer, which is why Designs for Health uses L-5-MTHF, the natural isomer, rather than the mixed (or racemic) form. This product uses the patented folate derivative, Quatrefolic®. This innovative form of folate has demonstrated high bioavailability, solubility, and long-lasting stability. Quatrefolic® L-5-MTHF has been shown to help increase blood folate levels much better than folic acid.*
As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.
Serving Size: One Capsule
Amount Per Serving
Folate (as Quatrefolic® [6S]-5-methyltetrahydrofolate, glucosamine salt) ... 1700 mcg DFE
Other Ingredients: Organic spinach powder, microcrystalline cellulose, cellulose (capsule), L-leucine.
Quatrefolic® is covered by U.S. Patent No. 7, 947, 662 and is a registered trademark of Gnosis S.p.A.
NOTICE
Color, size or shape may appear different between lots.
Store at room temperature. Keep out of reach of children.
